What are Exosomes ?

Exosomes are small message packets, approximately 30-150 nm in diameter, released by all cells in our body for intercellular communication. They are formed when the cell membrane folds inward during the maturation of endosomes, creating vesicles. These extracellular vesicles contain proteins, lipids, growth factors, and nucleic acids. Originating from their parent cells, exosomes carry the same information and can transmit it to target cells.

Exosomes can alter cell behavior by transferring genetic information, growth factors, proteins, and receptors between cells (acting as carriers). Due to these properties, they are effective in cell proliferation and tissue regeneration. Therefore, they are currently used in the field of Regenerative Medicine for treating various diseases.

Exosomes play an active role in the correction of degenerative tissue damage. For this reason, they have been actively used in many medical specialties and diseases.

Depending on their source, exosomes are classified into two groups: Autologous (derived from the same individual) and Allogeneic (derived from a different individual).

How Do You Get Exosomes ?

Autologous Exosomes

Exosomes obtained from the patient's own cells can be derived from various tissues (such as blood, adipose tissue, bone marrow, etc.). The tissue sample taken from the patient by the physician is preserved under appropriate conditions and sent to the relevant laboratory. Subsequently, exosomes are isolated from the tissue sample in the laboratory environment. Once ready and after passing suitable safety tests, the exosomes are preserved again under appropriate conditions and delivered to the physician for administration to the patient.

Allogeneic Exosomes

Allogeneic exosomes are obtained from a healthy donor and applied to another individual. The cellular content they carry is crucial, so their origin matters greatly. In allogeinic applications, exosomes are produced from Mesenchymal Stem Cells (MSCs) derived from pure, clean, non-toxic tissue, specifically newborn umbilical cord tissue. These exosomes, produced in specialized culture environments, undergo quality control, safety checks, and allergic tests before being prepared in vials ready for direct injection. They are then preserved under suitable conditions until they are delivered to the physician for administration to the patient.

These applications must be conducted in laboratories compliant with Good Manufacturing Practice (GMP) standards under the supervision of the Ministry of Health.

Which diseases are exosomes recommended for treating?

Eksozomların önerilen potansiyel kullanım alanları şu şekilde sıralanabilir;

  • Brain and neurosurgery
  • Neurology
  • Orthopedics and traumatology
  • Physical therapy and rehabilitation
  • Urology
  • Obstetrics and gynecology
  • Plastic and reconstructive surgery
  • Dermatology
  • General surgery
  • Cardiovascular surgery

You can also review frequently asked questions and articles about exosomes, and contact us with any questions you may have.

How is the use of exosomes administered?

There are various methods of application. The most common ones include intra-articular, intrathecal, intradermal, intramuscular, intratesticular, and intra-ovarian.

The product, brought under suitable storage conditions,

  • A gradual thawing process is performed. The product should be thawed at room temperature, away from direct heat sources.
  • The thawed product is ready for use.
  • Do not refreeze the product after it has been thawed!

Ideal Exosome Storage Conditions:

  • 24 months -80 °
  • 6 months -20 °
  • 1week+4 °

Our Latest Articles and Writings on Exosomes:

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