{"id":82,"date":"2024-02-15T10:38:04","date_gmt":"2024-02-15T10:38:04","guid":{"rendered":"http:\/\/www.hucreseltedavi.com\/?page_id=82"},"modified":"2024-07-11T09:40:18","modified_gmt":"2024-07-11T09:40:18","slug":"mezenkimal-kok-hucre-kaynakli-eksozomlar","status":"publish","type":"page","link":"http:\/\/www.hucreseltedavi.com\/en\/mezenkimal-kok-hucre-kaynakli-eksozomlar\/","title":{"rendered":"Exosomes Derived from Mesenchymal Stem Cells"},"content":{"rendered":"<h2 class=\"wp-block-heading has-primary-color has-text-color has-link-color wp-elements-2accfe10bd4929f74b8bccb82a3f9049\">What are Exosomes ?<\/h2>\n\n\n\n<p>Exosomes are small message packets, approximately 30-150 nm in diameter, released by all cells in our body for intercellular communication. They are formed when the cell membrane folds inward during the maturation of endosomes, creating vesicles. These extracellular vesicles contain proteins, lipids, growth factors, and nucleic acids. Originating from their parent cells, exosomes carry the same information and can transmit it to target cells.<\/p>\n\n\n\n<p>Exosomes can alter cell behavior by transferring genetic information, growth factors, proteins, and receptors between cells (acting as carriers). Due to these properties, they are effective in cell proliferation and tissue regeneration. Therefore, they are currently used in the field of Regenerative Medicine for treating various diseases.<\/p>\n\n\n\n<p>Exosomes play an active role in the correction of degenerative tissue damage. For this reason, they have been actively used in many medical specialties and diseases.<\/p>\n\n\n\n<p>Depending on their source, exosomes are classified into two groups: Autologous (derived from the same individual) and Allogeneic (derived from a different individual).<\/p>\n\n\n\n<div class=\"wp-block-group has-global-padding is-layout-constrained wp-block-group-is-layout-constrained\">\n<figure class=\"wp-block-image alignright size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"1200\" height=\"800\" src=\"https:\/\/www.hucreseltedavi.com\/wp-content\/uploads\/2024\/06\/eksozom-nedir-1200x800-1.jpg\" alt=\"\" class=\"wp-image-472\" style=\"width:auto;height:350px\" srcset=\"https:\/\/www.hucreseltedavi.com\/wp-content\/uploads\/2024\/06\/eksozom-nedir-1200x800-1.jpg 1200w, https:\/\/www.hucreseltedavi.com\/wp-content\/uploads\/2024\/06\/eksozom-nedir-1200x800-1-300x200.jpg 300w, https:\/\/www.hucreseltedavi.com\/wp-content\/uploads\/2024\/06\/eksozom-nedir-1200x800-1-1024x683.jpg 1024w, https:\/\/www.hucreseltedavi.com\/wp-content\/uploads\/2024\/06\/eksozom-nedir-1200x800-1-768x512.jpg 768w, https:\/\/www.hucreseltedavi.com\/wp-content\/uploads\/2024\/06\/eksozom-nedir-1200x800-1-18x12.jpg 18w\" sizes=\"(max-width: 1200px) 100vw, 1200px\" \/><\/figure>\n\n\n\n<h2 class=\"wp-block-heading has-primary-color has-text-color has-link-color wp-elements-2cd4ad614d7e82016e3317a998352c30\">How Do You Get Exosomes ?<\/h2>\n\n\n\n<p><\/p>\n<\/div>\n\n\n\n<h3 class=\"wp-block-heading has-primary-color has-text-color has-link-color has-small-font-size wp-elements-a01270cc92026e3bd088ba67412c7065\">Autologous Exosomes<\/h3>\n\n\n\n<p>Exosomes obtained from the patient's own cells can be derived from various tissues (such as blood, adipose tissue, bone marrow, etc.). The tissue sample taken from the patient by the physician is preserved under appropriate conditions and sent to the relevant laboratory. Subsequently, exosomes are isolated from the tissue sample in the laboratory environment. Once ready and after passing suitable safety tests, the exosomes are preserved again under appropriate conditions and delivered to the physician for administration to the patient.<\/p>\n\n\n\n<h2 class=\"wp-block-heading has-primary-color has-text-color has-link-color has-small-font-size wp-elements-15a5e300516f6616cd1319b0ad91d3e8\">Allogeneic Exosomes<\/h2>\n\n\n\n<p>Allogeneic exosomes are obtained from a healthy donor and applied to another individual. The cellular content they carry is crucial, so their origin matters greatly. In allogeinic applications, exosomes are produced from Mesenchymal Stem Cells (MSCs) derived from pure, clean, non-toxic tissue, specifically newborn umbilical cord tissue. These exosomes, produced in specialized culture environments, undergo quality control, safety checks, and allergic tests before being prepared in vials ready for direct injection. They are then preserved under suitable conditions until they are delivered to the physician for administration to the patient.<\/p>\n\n\n\n<p>These applications must be conducted in laboratories compliant with Good Manufacturing Practice (GMP) standards under the supervision of the Ministry of Health.<\/p>\n\n\n\n<p>Which diseases are exosomes recommended for treating?<\/p>\n\n\n\n<p>Eksozomlar\u0131n \u00f6nerilen potansiyel kullan\u0131m alanlar\u0131 \u015fu \u015fekilde s\u0131ralanabilir;<\/p>\n\n\n\n<ul>\n<li>Brain and neurosurgery<\/li>\n\n\n\n<li>Neurology<\/li>\n\n\n\n<li>Orthopedics and traumatology<\/li>\n\n\n\n<li>Physical therapy and rehabilitation<\/li>\n\n\n\n<li>Urology<\/li>\n\n\n\n<li>Obstetrics and gynecology<\/li>\n\n\n\n<li>Plastic and reconstructive surgery<\/li>\n\n\n\n<li>Dermatology<\/li>\n\n\n\n<li>General surgery<\/li>\n\n\n\n<li>Cardiovascular surgery<\/li>\n<\/ul>\n\n\n\n<p>You can also review frequently asked questions and articles about exosomes, and contact us with any questions you may have.<\/p>\n\n\n\n<p>How is the use of exosomes administered?<\/p>\n\n\n\n<p>There are various methods of application. The most common ones include intra-articular, intrathecal, intradermal, intramuscular, intratesticular, and intra-ovarian.<\/p>\n\n\n\n<p>The product, brought under suitable storage conditions,<\/p>\n\n\n\n<ul>\n<li>A gradual thawing process is performed. The product should be thawed at room temperature, away from direct heat sources.<\/li>\n\n\n\n<li>The thawed product is ready for use.<\/li>\n\n\n\n<li>Do not refreeze the product after it has been thawed!<\/li>\n<\/ul>\n\n\n\n<p>Ideal Exosome Storage Conditions:<\/p>\n\n\n\n<ul>\n<li>24 months -80 \u00b0<\/li>\n\n\n\n<li>6 months\u00a0-20 \u00b0<\/li>\n\n\n\n<li>1week+4 \u00b0<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity is-style-wide\"\/>\n\n\n\n<div style=\"height:75px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h3 class=\"wp-block-heading\">Our Latest Articles and Writings on Exosomes:<\/h3>\n\n\n<ul class=\"wp-block-latest-posts__list wp-block-latest-posts\"><li><a class=\"wp-block-latest-posts__post-title\" href=\"http:\/\/www.hucreseltedavi.com\/en\/2025\/02\/04\/kadin-dogum-ve-ivf-alaninda-mezenkimal-kok-hucre-tedavisi-ureme-sagliginda-yeni-ufuklar\/\">Kad\u0131n Do\u011fum ve IVF Alan\u0131nda Mezenkimal K\u00f6k H\u00fccre Tedavisi: \u00dcreme Sa\u011fl\u0131\u011f\u0131nda Yeni Ufuklar<\/a><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"http:\/\/www.hucreseltedavi.com\/en\/2025\/01\/13\/kadin-dogum-ve-ivf-alaninda-eksozom-tedavisi\/\">KADIN DO\u011eUM VE IVF ALANINDA EKSOZOM TEDAV\u0130S\u0130<\/a><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"http:\/\/www.hucreseltedavi.com\/en\/2024\/03\/21\/exosomes-as-a-novel-pathway-for-regulating-developmentand-diseases-of-the-skin-review\/\">Exosomes as a novel pathway for regulating developmentand diseases of the skin (Review)<\/a><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"http:\/\/www.hucreseltedavi.com\/en\/2024\/03\/21\/efficacy-of-microneedling-plus-human-stem-cellconditioned-medium-for-skin-rejuvenationa-randomized-controlled-blinded-split-face-study\/\">Efficacy of Microneedling Plus Human Stem CellConditioned Medium for Skin Rejuvenation:A Randomized, Controlled, Blinded Split-Face Study<\/a><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"http:\/\/www.hucreseltedavi.com\/en\/2024\/03\/21\/concise-review-developing-best-practice-models-forthe-therapeutic-use-of-extracellular-vesicles\/\">Concise Review: Developing Best-Practice Models forthe Therapeutic Use of Extracellular Vesicles<\/a><\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"<p>Eksozom Nedir? Eksozomlar v\u00fccudumuzdaki t\u00fcm h\u00fccrelerden sal\u0131nabilen ve h\u00fccreler aras\u0131 ileti\u015fimde g\u00f6revli olan yakla\u015f\u0131k 30-150 nm \u00e7ap\u0131ndaki mesaj paketleridir. Endozom h\u00fccrelerinin olgunla\u015fmas\u0131nda h\u00fccre zar\u0131 k\u0131vr\u0131larak kesecik olu\u015fturur. H\u00fccre d\u0131\u015f\u0131 vezik\u00fcller yap\u0131lar\u0131nda protein, lipid, b\u00fcy\u00fcme fakt\u00f6rleri ve n\u00fckleik asit bulundururlar. K\u00f6ken ald\u0131klar\u0131 h\u00fccre i\u00e7eri\u011fi ile o h\u00fccrenin bilgilerini ta\u015f\u0131makla birlikte bilgileri hedef h\u00fccreye iletirler. Eksozomlar; bir [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"_links":{"self":[{"href":"http:\/\/www.hucreseltedavi.com\/en\/wp-json\/wp\/v2\/pages\/82"}],"collection":[{"href":"http:\/\/www.hucreseltedavi.com\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"http:\/\/www.hucreseltedavi.com\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"http:\/\/www.hucreseltedavi.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.hucreseltedavi.com\/en\/wp-json\/wp\/v2\/comments?post=82"}],"version-history":[{"count":28,"href":"http:\/\/www.hucreseltedavi.com\/en\/wp-json\/wp\/v2\/pages\/82\/revisions"}],"predecessor-version":[{"id":523,"href":"http:\/\/www.hucreseltedavi.com\/en\/wp-json\/wp\/v2\/pages\/82\/revisions\/523"}],"wp:attachment":[{"href":"http:\/\/www.hucreseltedavi.com\/en\/wp-json\/wp\/v2\/media?parent=82"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}